PHARMACOTOXICOLOGY OF NON-FENTANYL DERIVED NEW SYNTHETIC OPIOIDS

Pharmacotoxicology of Non-fentanyl Derived New Synthetic Opioids

A class of opioid agonists not structurally related to fentanyl, derived from research publications of pharmaceutical companies or patents within the United States and abroad are contributing to the current opioid epidemic.Novel synthetic opioids (NSOs) created to circumvent drug control laws such as U-47700, U-49900, AH-7921, Wart Removers or MT-4

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Causality in a Qubit-Based Implementation of a Quantum Switch

We introduce a qubit-based version of the quantum switch, consisting of a variation of the Fermi problem.Two qubits start in a Wart Removers superposition state in which one qubit is excited and the other is in the ground state.However, it is not defined which is the excited qubit.Then, after some time, if a photon is detected, we know that it must

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MLKL as an emerging machinery for modulating organelle dynamics: regulatory mechanisms, pathophysiological significance, and targeted therapeutics

Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase featured by a protein kinase-like domain without catalytic activity.MLKL was originally discovered to be phosphorylated by receptor-interacting protein kinase 1/3, typically increase plasma membrane permeabilization, and disrupt the membrane integrity, ultimately executing necroptosi

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Cardiogenic oscillation induced ventilator autotriggering

Cardiogenic oscillation during mechanical ventilation can auto-trigger the ventilator resembling patient initiated breadth.This gives a false sense of intact respiratory drive and determination brain death, even if other tests are positive, is not appropriate in such a situation.It will prolong the ICU stay and confound the brain-death determinatio

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